ON THE SITE OF INTERACTION BETWEEN NaH2PO4 AND MgCl2 OR KCl IN THE PREVENTION OF »PHOSPHATE-STEROID-CARDIOPATHY«

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Abstract
A neutral mixture of NaH2PO4 and Na2HPO4 was introduced through the granuloma pouches of rats pre-treated with subcutaneous injections of 2[alpha]-methyl-9[alpha]-chlorocortisol (Me-Cl-COL). Infarct-like necroses in the heart, accompanied by nephrocalcinosis, were produced uniformly in all animals receiving this treatment. Animals who received KCL or MgCl2 in their drinking water, however, were effectively protected against the development of both the cardiopathy and the nephrocalcinosis. From these observations, it is concluded that the protection offered by K or Mg salts against the development of the phosphate-steroid-cardiopathy and the accompanying nephrocalcinosis is not due to a more local interference with the intestinal absorption of the phosphates.