Asymmetric Synthesis of 4-Acetoxy-3-hydroxyethylazetidin-2-one, a Key Intermediate for the Preparation of Penem and Carbapenem Antibiotics
- 1 January 1987
- journal article
- research article
- Published by CLOCKSS Archive in HETEROCYCLES
- Vol. 25 (1) , 241-244
- https://doi.org/10.3987/s-1987-01-0241
Abstract
Asymmetric synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one with desired stereochemistry has been achieved by employing [3 + 2] dipolar cycloaddition of a chiral nitrone with benzyl crotonate as a key reaction.Keywords
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