MinK-Related Peptide 1
- 22 June 2001
- journal article
- other
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 88 (12) , E84-7
- https://doi.org/10.1161/hh1201.093511
Abstract
—The HCN family of ion channel subunits underlies the currents If in heart and Ih and Iq in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a β subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a β subunit for the cardiac delayed rectifier IKr, these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.Keywords
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