Plasma Protein Binding and Therapeutic Drug Monitoring
- 31 December 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 2 (1) , 29-38
- https://doi.org/10.1097/00007691-198001000-00005
Abstract
Aspects of measurement of plasma protein-binding of drugs and the representation and interpretation of such data, together with the effect of altered binding on pharmacokinetics and the impact on therapeutic plasma drug concentration monitoring, are reviewed. In most instances, altered binding affects interpretation of plasma concentration data rather than causes a need for a change in the usual dosage regimen.This publication has 6 references indexed in Scilit:
- Differences in the protein binding of several drugs and bilirubin in serum and heparinized plasma of ratsLife Sciences, 1979
- Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for samplingClinical Pharmacology & Therapeutics, 1979
- Increased Plasma Protein Binding of Propranolol and Chlorpromazine Mediated by Disease-Induced Elevations of Plasma α1Acid GlycoproteinNew England Journal of Medicine, 1978
- Plasma Protein Binding of Diazepam after a Single Dose of Sodium OleateJournal of Pharmaceutical Sciences, 1978
- Alteration of plasma albumin in relation to decreased drug binding in uremiaClinical Pharmacology & Therapeutics, 1977
- Physical Methods for Studying Drug-Protein BindingPublished by Springer Nature ,1971