STUDIES ON THE ENZYMIC FORMATION OF DI-IODOTYROSINE BY A MICROSOMAL PREPARATION OF GOAT SUBMAXILLARY GLAND

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Abstract
SUMMARY Subcellular fractions of goat submaxillary gland catalysed the iodination of monoiodotyrosine to form di-iodotyrosine; the microsomal fraction was found to have maximum activity. The enzyme needed copper or hydrogen peroxide for its activity. Thiourea and thiouracil inhibited the enzymic activity. Manganese and ferric ions inhibited the enzymic formation of di-iodotyrosine. The enzyme was solubilized by sodium desoxycholate treatment.