The Interrelationship of Hypoxia, Erythropoietin, and the Renal Juxtaglomerular Cell.

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Abstract
Others have noted the frequent association of increased juxtaglomerular (JG) granularity and increased levels of plasma erythropoietin (EP) after the combined stimuli of underdistention of the renal arterial bed and hypoxia of the renal parenchyma. To separate these two stimuli, rats were subjected to hypoxia without hypovolemia by being kept at 1/2 atmospheric pressure for 12 hours. There was no change in the JG granularity and therefore, probably no change in their rate of secretion. However, EP levels were known to be high. This tends to disprove the hypothesis that the JG cells secrete EP.

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