SCLEREMA NEONATORUM TREATED WITH CORTICOTROPIN (ACTH)

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Abstract
Sclerema neonatorum1 is a peculiar induration of the skin and subcutaneous tissue that often starts in the buttocks and thighs and involves the remainder of the legs, the trunk, the arms, and the face. The soles, the palms, and the genitalia are spared. It is found in premature infants or in very young infants suffering from congenital debility, diarrheal conditions, dehydration, and circulatory stasis. There is associated marked lowering of body temperature; the skin is stiff, cold, and often mottled as in peripheral circulatory failure; and there is interference with activity, respiration, and sucking. When it appears, it is of very serious prognostic importance despite the fact that these infants have been treated for the primary disturbances such as dehydration, shock, and acidosis. Until recently, about 75% of the infants treated died. Reports of the successful treatment of sclerema neonatorum with corticotropin (ACTH) and cortisone in addition to the

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