Genetic Factors in Leucocyte Responses to Endotoxin: Further Studies in Mice

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Abstract
Comparative studies of the leucocyte responses of two strains of highly inbred mice, which radically differ in their susceptibility to the lethal effects of endotoxin, indicate that the proportion of neutrophils to mononuclear cells in the peritoneal cavity after the intraperitoneal injection of endotoxin appears to be a function of the relative toxicity of the endotoxin. Therefore, the extravascular accumulation of leucocytes and mononuclears at the site of endotoxin injection may be a function of mechanisms that are influenced by the susceptibility of the host to the toxic effects of endotoxins. The degree of susceptibility appears to be determined in great measure by the genetic constitution of the host.

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