?-Globin loci in homozygous ?-thalassemia intermedia
- 1 June 1983
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 63 (4) , 338-340
- https://doi.org/10.1007/bf00274758
Abstract
Homozygous β-thalassemia intermedia (TI) differs from thalassemia major (TM) in being less severe clinically. Associated α-thalassemia could account for the TI phenotype by reducing the α/non-α chain imbalance. We have analyzed the α loci of 9 TI and 11 TM patients by restriction endonuclease mapping. All the TM and 7 of the TI patients have the normal complement of four α-globin genes (αα/αα). One TI patient has three α-globin genes (αα/-α), and another TI patient, has five α genes (αα/ααα).This publication has 9 references indexed in Scilit:
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