Complex Segregation Analysis of Diabetes Mellitus

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Abstract
Complex segregation analysis was applied to 1293 nuclear families [from Mexico City, Mexico] each with at least 1 diabetic patient. The families were divided into 2 groups depending on the proband''s treatment: insulin-dependent (IDG) and insulin-independent (IIG). Heterogeneity analysis has revealed a highly significant difference in the IIG group when families were divided into different mating types. The higher recurrence risk was found in the group with affected mothers. Also evidence for a major recessive gene was found in the IIG group, while it was not possible to distinguish between the hypothesis for absence of a major locus and absence of polygenic inheritance in the IDG group. Risks to develop the disease were calculated for a few typical situations.

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