Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus
- 1 August 1987
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 61 (8) , 2639-2641
- https://doi.org/10.1128/jvi.61.8.2639-2641.1987
Abstract
Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.This publication has 23 references indexed in Scilit:
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