Biodegradation of alpha-hexachlorocyclohexane
- 1 January 1975
- journal article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 291 (1) , 79-87
- https://doi.org/10.1007/bf00510822
Abstract
Alpha-hexachlorocyclohexane (α-HCH) is dechlorinated by enzymes contained in rat liver cytosol and microsomes. An evidence was obtained that in the cytosol there are two α-HCH dechlorinating enzymes at least: one operates only in the presence of reduced glutathione (GSH) and catalyzes dechlorinations associated with the formation of another hydrophilic product. This product is probably a conjugate of the α-HCH-residue with GSH. The other cytoplasmic α-HCH-dechlorinase requires no additions. The microsomes, too, contain two α-HCH dechlorinases at least: one is stimulated by GSH, the other by NADPH.Keywords
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