Altered Glycosylation of Surface Glycoproteins in Tumor Cells and its Clinical Application
- 28 July 1989
- journal article
- review article
- Published by Wiley in Pigment Cell Research
- Vol. 2 (4) , 304-308
- https://doi.org/10.1111/j.1600-0749.1989.tb00209.x
Abstract
Appearance of large Asn-linked sugar chains in the surface glycoprotein is one of the most widely found phenomena in malignant cells and is called the Warren-Glick phenomenon. Comparative study of the sugar chain structures of the surface glycoproteins of cultured cells and their malignant transformants revealed that the altered glycosylation is induced by enhancement of N-acetyl-glucosaminyltransferase V. The change seems to be highly correlated with the metastatic potential of tumor cells.Keywords
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