Erythema Multiforme Associated with Sulfamethoxypyridazine Administration

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Abstract
SULFONAMIDE therapy has always held an important place in pediatrics. Hypersensitivity reactions to this group of drugs have been seen frequently in the past. Sulfamethoxypyridazine,‡ a newer sulfonamide with special appeal for pediatric use since effective levels are maintained when it is given at twenty-four-hour intervals, has proved to be no exception. The medical literature concerning such experience with sulfamethoxypyridazine has been limited to adults. Three cases of erythema multiforme showing the Stevens–Johnson syndrome, occurring in children receiving sulfamethoxypyridazine, have been seen on the Pediatric Service of Grady Memorial Hospital. Two of these patients were siblings, simultaneously affected, 1 of . . .

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