Asian‐Pacific consensus statement on the management of chronic hepatitis B: a 2005 update
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Open Access
- 21 May 2005
- journal article
- review article
- Published by Wiley in Liver International
- Vol. 25 (3) , 472-489
- https://doi.org/10.1111/j.1478-3231.2005.01134.x
Abstract
A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires revision and update. New data were presented, discussed and debated in an expert pre-meeting to draft a revision. The revised contents were finalized after discussion in a general meeting of APASL. Conceptual background, including the efficacy and safety profile of currently available and emerging drugs, was reviewed. Nineteen recommendations were formed and unresolved issues and areas for further study were suggested. The current therapy of chronic hepatitis B is modestly effective but not satisfactory. The development of new drugs and new strategies is required to further improve the outcomes of treatment.Keywords
This publication has 146 references indexed in Scilit:
- 46 Three year study of adefovir dipivoxil (ADV) demonstrates sustained efficacy in presumed precore mutant chronic hepatitis B (CHB) patients in a long term safety and efficacy study (LTSES)Journal of Hepatology, 2004
- A randomised double-blind phase II study of lamivudine (LAM) compared to lamivudine plus adefovir dipovoxil (ADV) for treatment naïve patients with chronic hepatitis B (CHB): Week 52 analysisJournal of Hepatology, 2003
- Long-term safety of adefovir dipivoxil (ADV) 10 MG once daily for chronic hepatitis B (CHB): An integrated analysis of two phase III studiesJournal of Hepatology, 2003
- EASL INTERNATIONAL CONSENSUS CONFERENCE ON HEPATITIS B13–14 September, 2002Geneva, SwitzerlandJournal of Hepatology, 2003
- Interferon-α for HBeAg-positive chronic hepatitis BJournal of Hepatology, 2003
- Safety and efficacy of long-term adefovir dipivoxil (ADV) for lamivudine-resistant (LAM-R) HBV in HIV infected patientsJournal of Hepatology, 2002
- Lamivudine as Initial Treatment for Chronic Hepatitis B in the United StatesNew England Journal of Medicine, 1999
- Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapyHepatology, 1999
- Beneficial effect of prednisolone withdrawal followed by human lymphoblastoid interferon on the treatment of chronic type B hepatitis in Asians: a randomized controlled trialJournal of Hepatology, 1994
- Hepatitis B Virus RNA Transcripts and DNA in Chronic Liver DiseaseNew England Journal of Medicine, 1986