Design, Synthesis, and Evaluation of the First Mechanism-Based Inhibitor of Glucosamine 6-Phosphate Synthase

This publication has 21 references indexed in Scilit:

• Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 å crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase
  Structure, 1996
• Mechanism-based inactivation of ribonuclease A
  The Journal of Organic Chemistry, 1995
• Glutamate .gamma.-Semialdehyde as a Natural Transition State Analog Inhibitor of Escherichia coli Glucosamine-6-phosphate Synthase
  Biochemistry, 1995
• Synthesis and biological activities of peptides containing N3-(S)-2-bromosuccinamoyl-(S)-2,3-diaminopropanoic acid
  European Journal of Medicinal Chemistry, 1994
• Actions of Antiulcer Drugs
  Science, 1993
• Concise, Stereocontrolled Synthesis of the C4 Epimers of Anticapsin and Bacilysin: Revision of the Configurations of the Natural Products
  Australian Journal of Chemistry, 1993
• Molecular cloning and overexpression of the glucosamine synthetase gene from Escherichia coli
  Biochimie, 1988
• Inactivation of glucosamine-6-phosphate synthetase from Salmonella typhimurium LT2 by fumaroyl diaminopropanoic acid derivatives, a novel group of glutamine analogs
  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
• A novel peptide delivery system involving peptidase activated prodrugs as antimicrobial agents. Synthesis and biological activity of peptidyl derivatives of 5-fluorouracil
  Journal of Medicinal Chemistry, 1984
• The inactivation of glucosamine synthetase from bacteria by anticapsin, the C-terminal epoxyamino acid of the antibiotic tetaine
  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1984