Effect of O2 at high ambient pressure on blood flow and O2 consumption of the kidney

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Abstract
Renal blood flow of chloralosed dogs, measured while they breathed 100% O2 at ambient pressures of 1, 2, 3, and 4 atm abs (OHP), declined exponentially as an inverse function of PiOO2 until at 4 atm O2 it was 57% of control. Denervating the kidney did not affect the response, the mechanism of which remains unknown. Mean arterial blood pressure increased to 112% of control and heart rate decreased to 60% of control as O2 pressure increased from 1 to 3 atm abs, suggesting a generalized systemic vasoconstriction in which the kidney participated. We estimate that the measured decrease in renal blood flow during OHP would account for approximately 20% of the total decrease in peripheral blood flow. Renal O2 consumption was not affected by OHP. This can be accounted for in terms of a constant filtered and reabsorbed sodium load Note: (With the Technical Assistance of D. R. Wilson) hyperbaric oxygenation; kidney circulation; environmental pressure Submitted on February 20, 1964

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