The vitamin B12-binding systems of isolated intestine of the rat
- 1 April 1958
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 68 (4) , 592-597
- https://doi.org/10.1042/bj0680592
Abstract
The measurement of uptake of radioactive vitamin B12 by isolated intestine has been described. The effect of pseudovitamin B12, an anti-vitamin B12 and the lactone of vitamin B12 on uptake of radioactive vitamin B12 has been studied. Two vitamin B12-binding systems were demonstrated, one competitive and the other non-competitive. The implications of the non-competitive binding system in relation vitamin B12 uptake are discussed.Keywords
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