Renin, Aldosterone and Glucagon in the Natriuresis of Fasting

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Abstract
IN view of man's evolutionary origins, it is clear that our ancestors who emerged from the sodium-rich environment of the oceans to dry land had to develop a mechanism to control internal salinity. Different species have developed different modes for control of body sodium, and a major regulatory factor in human beings is the mineralocorticoid, aldosterone, described by Simpson and Tait in 1951.1 Although the other adreno-cortical hormones have diverse actions on various tissues at different levels throughout the body, aldosterone appears to function at a solitary locus, the distal tubule of the kidney, and to have the single function . . .