Expression of Chicken Integrin .BETA.1 Subunit in Rat PC12 Cells.

1 January 1991

journal article
Published by Japan Society for Cell Biology in Cell Structure and Function

Vol. 16 (2) , 135-139
https://doi.org/10.1247/csf.16.135

Abstract

We transfected rat pheochromocytoma (PC12) cells with a cDNA encoding chicken integrin beta 1 subunit. The chicken integrin beta 1 subunit produced in stable transfectants associated with two major alpha subunits of rat integrins to form interspecific chimeric receptors. These receptors mediated cell spreading and initial neurite outgrowth on laminin as did corresponding endogenous integrins, although they were slightly less effective in inducing cell adhesion to laminin. These results indicate that chicken integrin beta 1 may functionally substitute for beta 1 subunit of rat integrins in PC12 cells. Apparently, the structure of the integrin beta 1 subunit is highly conserved in the evolution of these species.

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