Cross-sectional Study of Osteopenia with Quantitative MR Imaging and Bone Densitometry

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Abstract
PURPOSE: To evaluation the cancellous bone–induced intravoxel spin dephasing rate (R2’) and its relationship to bone mineral density and marrow fat and to examine these parameters as predictors of vertebral fracture status. MATERIALS AND METHODS: R2’ and R2, the rate constants for reversible and irreversible spin dephasing, and marrow fat fraction were measured in the lumbar vertebrae and proximal femur. One hundred thirty-nine subjects (mean age, 62.4 years ± 11.4 [SD]; 33 men, 106 women) had spinal dual-energy x-ray absorptiometric bone mineral density (BMD) T scores ranging from +3 to −5. R2’, BMD, and bone marrow composition as determinants of vertebral fracture status were examined. RESULTS: Strongest single predictors of fracture status for BMD and R2’ were the Ward triangle (r2 = 0.48) and trochanter (r2 = 0.37), respectively. Combined, the two parameters and sites increased fracture prediction (r2 = 0.62), whereas the combination of multiple BMD sites did not. Multivariate regression involving mar...