STRUCTURAL AND FUNCTIONAL INVESTIGATION OF POLYMYXINS - STRUCTURE AND BIOLOGICAL PROPERTIES OF POLYMYXIN-M ANALOGS
- 1 January 1989
- journal article
- research article
- Vol. 34 (1) , 20-24
Abstract
The effect of proteinases of plant and microbial origin on polymyxin M was studied. It was shown that this antibiotic was absolutely stable to the effect of papain and ficin. On hydrolysis with subtilysine there formed polymyxin decyclized analogs not described carlier. Their isolation, purification and biological activity are described. The structure of these compounds was assessed by one- and two-dimentional 1H NMR spectroscopy. The role of various functional groups, their space orientation and impact on antimicrobial activity of the compounds are discussed.This publication has 5 references indexed in Scilit:
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