Clofibrate-induced myopathy in patients with diabetes insipidus.

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Abstract
Clofibrate was considered a relatively safe antidiuretic in the treatment of diabetes insipidus. Four cases of clofibrate-induced myopathy were recently discovered in patients with diabetes insipidus due to hypothalamic lesions. Physicians should be aware of its occurrence and carefully monitor serum levels of creatine phosphokinase, glutamic oxalacetic transaminase and glutamic-pyruvic transaminase during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.

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