A comparison of the cardiovascular actions of AQ 110 with those of isoprenaline and salbutamol

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Abstract
1 . AQ 110 is a β-adrenoceptor agonist which, like isoprenaline and salbutamol, acts directly on the receptors. 2 . Compared with isoprenaline, AQ 110 has relatively stronger actions on bronchial and vascular smooth muscle (β2-adrenoceptors) than stimulant effects on heart muscle (β1-adrenoceptors). The β2-selectivity of AQ 110 is, however, much less than that of salbutamol, mainly due to the weak cardiac actions of the latter. 3 . At doses which were equipotent in decreasing the bronchoconstrictor effect produced by a standard dose of 5-hydroxytryptamine, AQ 110 had marginally less hypotensive action than salbutamol and considerably less than isoprenaline. 4 . Although AQ 110, unlike salbutamol, possesses a catechol group it was found not to be a substrate for catechol-O-methyl transferase and this is considered to account for its significantly prolonged action, compared with isoprenaline, in vivo.

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