The Metal Complexes of Peptides and Related Compounds. I. Copper(II) Complexes of O-Phosphorylserylglutamic Acid in Aqueous Solution.
- 1 January 1965
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 19 (6) , 1445-1468
- https://doi.org/10.3891/acta.chem.scand.19-1445
Abstract
The complex formation between copper (n) and O-phosphoryl-serylglutamic acid has been studied potentiometrically in 0.15 [image] K(NO3) medium at 25[degree], using glass and copper amalgam electrodes. Species of type MHqA with q equal to 2, 1, 0,-1 dominate in the concentration ranges investigated (Table 4). In addition, the existance of some MHqA2, (1,0,2) is indicated. The experimental data, [image](log h)CA, C[image] and [eta] (log.h)r, CM, were first treated by integration methods in order to obtain the free ligand concentration and the contribution of copper (n) complexes to the total peptide concentration, assuming any set of complex equilibria MpH0Ay. Equations were derived according to the approach indicatedy by Silfien. The formula of the main complexes and preliminary values of corresponding equilibrium constants were evaluated graphically. These constants were refined by a generalized least square method, using the high speed computer, SAAB D21, and the Letagrop program.This publication has 1 reference indexed in Scilit:
- Hydrolysis of Phosphopeptides. II. Leucine Aminopeptidase Hydrolysis of Free and O-Phosphorylated Serine Peptides.Acta Chemica Scandinavica, 1965