Age and gender influence muscle sympathetic nerve activity at rest in healthy humans.
- 1 April 1993
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 21 (4) , 498-503
- https://doi.org/10.1161/01.hyp.21.4.498
Abstract
Muscle sympathetic nerve activity at rest increases with age in humans. The respective influences of the aging process per se and gender on this increase and whether age and gender effects on muscle sympathetic nerve activity can be identified with plasma norepinephrine concentrations, however, have not been established. To examine these issues, nine young women (aged 24 +/- 1 years; mean +/- SEM), eight young men (aged 26 +/- 1 years), seven older women (aged 63 +/- 1 years), and eight older men (aged 66 +/- 1 years) were studied. All were healthy, normotensive (blood pressure < 140/90 mm Hg), nonobese (< 20% above ideal weight), unmedicated, nonsmokers engaged in minimal to recreational levels of chronic physical activity. Arterial blood pressure (manual sphygmomanometry, brachial artery), heart rate, muscle sympathetic nerve activity (peroneal microneurography), and antecubital venous plasma norepinephrine concentrations (radioenzymatic assay) were determined during quiet supine resting conditions. Body weight was higher in men, but there were no age-related differences, whereas estimated body fat (sum of skinfolds) was higher in women and in the older groups (p < 0.05). Estimated daily energy expenditure, arterial blood pressure, and heart rate were not different among the groups. Both muscle sympathetic nerve activity burst frequency and burst incidence at rest were progressively higher in the young women, young men, older women, and older men (10 +/- 1 versus 18 +/- 2 versus 25 +/- 3 versus 39 +/- 5 bursts/min and 16 +/- 1 versus 30 +/- 4 versus 40 +/- 3 versus 61 +/- 6 bursts/100 heartbeats, respectively; all p < 0.05 versus each other).(ABSTRACT TRUNCATED AT 250 WORDS)Keywords
This publication has 19 references indexed in Scilit:
- Clinical implications of pathophysiologic changes in the midlife hypertensive patientAmerican Heart Journal, 1991
- Age-related changes in muscle sympathetic nerve activity in essential hypertension.Hypertension, 1989
- Peripheral Sympathetic Neural Activity in Conscious HumansAnnual Review of Physiology, 1988
- The prevalence of peripheral arterial disease in a defined population.Circulation, 1985
- Muscle sympathetic activity and plasma noradrenaline in normotensive and hypertensive manActa Physiologica Scandinavica, 1983
- Measurements of plasma norepinephrine concentrations in human primary hypertension. A word of caution on their applicability for assessing neurogenic contributions.Hypertension, 1983
- Age-dependence of hypertensive-normotensive differences in plasma norepinephrine.Hypertension, 1983
- Enhanced plasma norepinephrine response to upright posture and oral glucose administration in elderly human subjectsMetabolism, 1980
- Sympathetic Nervous System and Aging in ManEndocrine Reviews, 1980
- Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamineLife Sciences, 1977