3H-imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium
- 1 May 1982
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 77 (1) , 94-97
- https://doi.org/10.1007/bf00436105
Abstract
The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.Keywords
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