Modulation of cellular macromolecular synthesis by coronavirus: implication for pathogenesis
- 1 October 1994
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 68 (10) , 6815-9
- https://doi.org/10.1128/jvi.68.10.6815-6819.1994
Abstract
Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced only slightly. By contrast, the mRNA levels of interleukin 1 beta, colony-stimulating factor 1 receptor, and tumor necrosis factor alpha increased following infection.Keywords
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