Viral Therapy for Glioblastoma
- 1 May 2003
- journal article
- review article
- Published by Wolters Kluwer Health in The Cancer Journal
- Vol. 9 (3) , 167-179
- https://doi.org/10.1097/00130404-200305000-00005
Abstract
Malignant gliomas remain amongst the most difficult cancer to treat. Viral-based gene therapies have been employed for the last decade in preclinical and clinical modes as a novel treatment modality. In this review, such therapies are summarized. The overwhelming majority of clinical studies point one to conclude that methodologies that will increase tumor infection/transduction will lead to enhanced therapeutic results.Keywords
This publication has 67 references indexed in Scilit:
- Oncolytic virusesNature Reviews Cancer, 2002
- The Molecular Genetics of Lentiviral Vectors - Current and Future PerspectivesCurrent Gene Therapy, 2001
- Temozolomide for recurrent high-grade gliomaSeminars in Oncology, 2001
- Cancer gene and oncolytic virus therapySeminars in Oncology, 2001
- Cancer gene therapy by adenovirus-mediated gene transfer.Current Gene Therapy, 2001
- Prodrug activation enzymes in cancer gene therapyThe Journal of Gene Medicine, 2000
- Gene Therapy for Brain TumorsBrain Pathology, 1995
- Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomasThe Lancet, 1995
- In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain TumorsScience, 1992
- Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirusCell, 1983