Studies on the Indochina I/CDC Strain of Plasmodium falciparum in Colombian and Bolivian Aotus Monkeys and Different Anophelines

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Abstract
The Indochina I/CDC strain of P. falciparum was isolated from a physician returning to the USA after working in the refugee camps along the Thailand-Kampuchean border. The strain was established in splenectomized Aotus monkeys from Columbia after being grown in vitro for 50 days. During the first 3 passages in Colombian monkeys, the parasites were not infective to Bolivian Aotus monkeys. After 6 intervening passages in Saimiri sciureus monkeys, the parasites produced high parasitemias in both Colombian and Bolivian Aotus, but gametocytes were no longer produced. Mosquito infections were obtained only during the first 3 passages in the Colombian monkeys. The most susceptible mosquito was Anopheles freeborni, followed by A. dirus, A. stephensi, A. maculatus, A. culicifacies, and, rarely, A. gambiae. Sporozoites were found in the salivary glands of the A. freeborni, A. dirus, A. stephensi, and A. maculatus.

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