Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation
- 1 May 2000
- journal article
- Published by Wiley in The FASEB Journal
- Vol. 14 (7) , 847-858
- https://doi.org/10.1096/fasebj.14.7.847
Abstract
Glycosphingolipids, including gangliosides, are emerging as signaling intermediates of extracellular stimuli. Because mitochondria play a key role in the orchestration of death signals, we assessed...Keywords
Funding Information
- National Institute on Alcohol Abuse and Alcoholism (AA 09526)
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