Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers
- 1 February 1995
- journal article
- pharmacodynamics
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 47 (6) , 497-502
- https://doi.org/10.1007/bf00193701
Abstract
The ex vivo effect of triflusal and acetylsalicylic acid (ASA) on platelet interaction with the subendothelium using the Baumgartner perfusion system (wall shear rate 350 s−1) was assessed in blood from 10 healthy volunteers who given a 15-day course of triflusal 600 mg per day and ASA 400 mg per day in a crossover trial. The percentage of platelets on the subendothelium showed a decrease of 62% in samples from subjects on ASA and a decrease of 93% in those from subjects on triflusal (PP−1 triflusal did not modify the percentage of the subendothelium covered by platelets. HTB 1 mmol·l−1 inhibited adhesion (26%) and aggregates (18%). We conclude that HTB participates in the ex vivo effects of triflusal on the platelet-subendothelium interaction.Keywords
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