Experimental partial sympathicotonia, and effects of some drugs on it in restraint and water immersion stressed animals.

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Abstract
The contractile response to acetylcholine (ACh) of the isolated duodenum from the restraint and water immersion stressed (RWIS) mouse was enhanced by stress for 1 h and reached a maximum after 3 h stress followed by a decrease. This rise in the response is not due to a change in the affinity to ACh but due to the increase of the intrinsic activity. The contractile response to KCl was augmented only when the concentration of KCl was high, while the response to BaCl2 was only slightly enhanced in the stressed animal. The relaxing response to noradrenaline (NA, norepinephrine) of the isolated rat duodenum was reduced by stress. Such a reduced response to NA was more marked than the enhanced response to ACh in the vas deferens isolated from the stressed animal. Pretreatment of the RWIS mouse with antiadrenergic or cholinergic drugs blocked the enhancement of response to ACh of the isolated duodenum from the mouse. These results contrasted with the effects on the reduced response to ACh of the isolated duodenum from the SART stressed (repeated cold stressed) mouse. The pre-administration of psychotropic drugs showed marked suppression on the enhancement of response of the duodenum of the RWIS animal, but there was a quantitative difference between the RWIS and SART animals. Pretreatment with a neurosedative, Neutrotropin (NSP), caused marked suppressive action. The duodenum and the vas deferens of the RWIS animal are in a state of sympathicotonia, namely partial sympathicotonia.

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