Regulation of Intestinal UDP Glucuronosyltransferase Activity by Fatty Acids in the Rat

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Abstract
The regulation of the intestinal UDP glucuronosyltransferase activity in the rat by essential fatty acids was studied by intraperitoneal administration of elaidic and linoleic acids at doses of 40 mg/kg (0.14 mmol/kg) and 200 mg/kg (0.71 mmol/kg) to rats fed standard diet, fat-free diet or fat-free diet supplemented by cholesterol. Fat-free diets doubled mucosal UDP glucuronosyltransferase activity as compared to the activity in rats fed standard diets. The administration of fatty acids had no effect on enzyme activity in rats fed standard diet whereas in rats fed fat-free diets the UDP glucuronosyltransferase activity decreased to the same level as in rats fed standard diets. This is to judge that essential fatty acids may control the mucosal UDP glucuronosyltransferase activity by regulating possibly the microenvironment of the enzyme as the protein content of mucosal postmitochondrial supernatant remained constant.