Drug Metabolism and Therapeutics

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Abstract
THE rapidly expanding number of therapeutic agents in use and the widespread administration of multiple medications to patients demand an increased awareness of both the metabolic effects of drugs and the possible effects of one drug on the metabolism of another. Studies during the past decade have shown dramatically that the duration and intensity of action of many drugs in animals depend on the activities of drug-metabolizing enzymes located primarily in the endoplasmic reticulum of the liver cell. These enzymes catalyze the metabolism of therapeutic agents by many pathways, such as hydroxylation, dealkylation, deamination, sulfoxidation, azo-link reduction and glucuronide formation. . . .