Occurrence in vivo of sister chromatid exchanges at the same locus in successive ceil divisions caused by nonrepairable lesions induced by gamma rays
- 1 January 1988
- journal article
- research article
- Published by Wiley in Environmental and Molecular Mutagenesis
- Vol. 11 (2) , 183-193
- https://doi.org/10.1002/em.2850110204
Abstract
The capacity of lesions induced by gamma radiation to produce sister chromatid exchanges (SCE) in successive divisions in mouse bone marrow cells in vivo was evaluated using a protocol for the three‐way differentiation of sister chromatids.Evidence was obtained that exposure to gamma radiation induces DNA lesions that result in the formation of SCE at the same locus in two successive cell divisions. The relevance of this observation with respect to DNA repair and mutagenesis is discussed.Keywords
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