Review : Progesterone and Recovery after Traumatic Brain Injury: An Overview
- 1 November 1998
- journal article
- Published by SAGE Publications in The Neuroscientist
- Vol. 4 (6) , 435-442
- https://doi.org/10.1177/107385849800400615
Abstract
After traumatic brain injury (TBI), female animals often show better cognitive and behavioral recovery than male animals. In female animals, this advantage is conferred by higher levels of systemic progesterone at the time of injury. In rats, postmortem examination of brain tissue reveals that pseudo-pregnant female rats (high progesterone, low estrogen) have virtually no cerebral edema compared with male rats and low- progesterone-state normal cycling female rats after TBI. Progesterone injections can also eliminate cerebral edema in brain-injured male rats. Sex differences in the outcome of TBI highlight the importance of consid ering the timing of therapy and hormonal fluctuations in developing safe and effective treatments for CNS injury. NEUROSCIENTIST 4:435-442, 1998Keywords
This publication has 41 references indexed in Scilit:
- Steroid Modulation of the GABA A Receptor Complex: Electrophysiological StudiesPublished by Wiley ,2007
- Progesterone as a neurosteroid: Actions within the nervous systemCellular and Molecular Neurobiology, 1996
- Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA ReceptorsJournal of Neuroendocrinology, 1995
- Prognostic effect of timing of surgery during menstrual cycle in premenopausal breast‐cancer patientsInternational Journal of Cancer, 1994
- Progesterone Facilitates Cognitive Recovery and Reduces Secondary Neuronal Loss Caused by Cortical Contusion Injury in Male RatsExperimental Neurology, 1994
- Bilateral Frontal Cortical Contusion in Rats: Behavioral and Anatomie ConsequencesJournal of Neurotrauma, 1994
- Hypoperfusion and vasoreactivity in the thalamus and cerebellum after stroke.Stroke, 1993
- Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cellsThe Journal of Steroid Biochemistry and Molecular Biology, 1992
- Hormonal state affects recovery from frontal cortex lesions in adult female ratsBehavioral and Neural Biology, 1987
- Neuro-steroids: 3β-hydroxy-δ5-derivatives in rat and monkey brainJournal of Steroid Biochemistry, 1987