La pathologie tumorale du thorotrast chez l’homme

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Abstract
A study of the autopsy material of the Institute of Pathology of Strasbourg contains 22 cases of thorotrastosis in the period from 1945 to 1960. Together with thorium poisoning, five patients showed a primary carcinoma of the liver or biliary apparatus, 2 patients showed angioplastic endothelial sarcoma and three patients revealed epitheliomas. These findings exceeded the usual incidence of malignancy expected for male subjects as well as in those autopsied for cirrhosis of the liver. The role of thorotrast in cancer genesis is undetermined. Three probabilities are suggested and discussed but the final conclusion implicates thorium radioactivity and a co-cancerogenic effect.

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