Maokonine, Hypertensive Principle of Ephedra Roots1

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Abstract
From an Oriental medicine „mao–kon”, Ephedra roots, which has been said to possess the opposite therapeutic effects as compared with its aerial counterpart „mao”, Ephedra herb, has been isolated L–tyrosine betaine. Since tyrosine betaine is the first time to be isolated from natural sources, it is designated as maokonine. It may be worthy to note that maokonine showed the hypertensive activity comparable with the action of ephedrine, the main alkaloid of the crude drug „mao”, but contrary to the effect of the original crude drug „mao–kon”.

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