Disseminated Intravascular Coagulation after Factor IX Complex Resolved Using Purified Factor IX Concentrate
- 15 October 1991
- journal article
- case report
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 115 (8) , 621-622
- https://doi.org/10.7326/0003-4819-115-8-621
Abstract
Patients with hemophilia B can be effectively treated with prothrombin complex concentrates (factor IX complex) that contain factors II, VII, IX, and X (1). A complication of therapy with factor IX complex is disseminated intravascular coagulation, attributed in part to activated factors in factor IX complex (2). We describe a patient with hemophilia B who developed disseminated intravascular coagulation while being treated with factor IX complex for a cerebellar hemorrhage. The patient's therapy was switched from factor IX complex to monoclonal antibody-purified factor IX (Mononine, Armour, Blue Bell, Pennsylvania), and the disseminated intravascular coagulation resolved.Keywords
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