Congenital muscular dystrophy

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Abstract
We performed this study to characterize the merosin-positive form of CMD (MP-CMD) clinically and pathologically. We selected patients with the Occidental, non-FCMD, who fulfilled the following diagnostic criteria: (1) muscle weakness and hypotonia during early infancy, delayed developmental milestones, or apparent muscle weakness when they began to walk, (2) no CNS symptoms except for mild mental retardation, (3) no brain CT/MRI abnormalities except for white matter lucency, (4) muscle findings consisting of necrotic and regenerating processes, (5) normal immunohistochemistry and immunoblotting to antibodies to dystrophin and dystrophin-associated glycoproteins. We applied an antimerosin antibody to the muscle biopsy specimens to subdivide these patients into the merosin-positive and merosin-negative groups.