Elucidation of the genome organization of tobacco mosaic virus
Open Access
- 29 March 1999
- journal article
- review article
- Published by The Royal Society in Philosophical Transactions Of The Royal Society B-Biological Sciences
- Vol. 354 (1383) , 587-591
- https://doi.org/10.1098/rstb.1999.0410
Abstract
Proteins unique to tobacco mosaic virus (TMV)–infected plants were detected in the 1970s by electrophoretic analyses of extracts of virus–infected tissues, comparing their proteins to those generated in extracts of uninfected tissues. The genome organization of TMV was deduced principally from studies involving in vitro translation of proteins from the genomic and subgenomic messenger RNAs. The ultimate analysis of the TMV genome came in 1982 when P. Goelet and colleagues sequenced the entire genome. Studies leading to the elucidation of the TMV genome organization are described.Keywords
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