Synthesis of thieno- and furo-pyrimidinethiones
- 1 January 1969
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- No. 14,p. 1937-1939
- https://doi.org/10.1039/j39690001937
Abstract
Substituted thiophens carrying adjacent amino- and cyano-groups have been converted into the corresponding pyrimidinethione derivatives in 30–70% yield by condensation with thioamides. Acylation of the thiophen followed by cyclisation in acidic solution gave the corresponding pyrimidones. The same reactions were used successfully with analogous furan compounds.Keywords
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