Comparison of clobetasol propionate and betamethasone-17,21-dipropionate with reference to adrenal suppression
Open Access
- 1 July 1979
- journal article
- clinical trial
- Published by Medical Journals Sweden AB in Acta Dermato-Venereologica
- Vol. 59 (4) , 372-374
- https://doi.org/10.2340/0001555559372374
Abstract
32 adult hospitalized patients with common skin disorders were controlled in a double-blind comparison study with clobetasol propionate (Dermovat) and betamethasone-17,21-dipropionate (Diproderm) with regard to adrenal suppression. The latter, when assessed by plasma cortisol, was significantly greater in the dermovat-treated groups after the 1st and 2nd week with daily treatment with both 25 g and 15 g ointment. Daily treatment of skin areas greater than 25% with 25 g Diproderm also showed clear adrenal suppression, whereas no such effect was obtained with daily treatment with 10 g Diproderm of skin areas greater than 15%. In all cases, plasma cortisol levels were normal 1--2 weeks after the end of topical treatment.Keywords
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