Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
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- 13 August 2001
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 4 (9) , 873-874
- https://doi.org/10.1038/nn0901-873
Abstract
Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction.Keywords
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