CARDIOVASCULAR FUNCTION IN ANESTHETIZED MINIATURE SWINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 29  (2) , 200-208
Abstract
Cardiovascular function in miniature swine anesthetized with pentobarbital was studied under control conditions and in response to catecholamines, baroreceptor inhibition, bilateral vagotomy and vagal nerve stimulation. Aortic pressure, heart rate, intraventricular pressure and its maximum rate of increase during contraction, carotid blood flow and resistance, femoral blood flow and resistance, and renal blood flow and resistance were measured. The cardiovascular effects of norepinephrine, epinephrine and isoproterenol were similar to those in other mammals, and the adrenergic receptor mechanisms were susceptible to blockade with phentolamine or propranolol. Inhibition of the carotid baroreceptors was accompanied by elevation of aortic pressure, reflex bradycardia and increased femoral and renal resistances. Bilateral vagotomy was followed by hypertension, tachycardia and increased renal resistance. Changes in femoral resistance to these procedures differed between the 2 strains of miniature swine studied. Stimulation of the peripheral end of either vagus nerve was accompanied by bradycardia without hypotension.

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