POSTMORTEM HEPATIC GLYCOGENOLYSIS IN HYPERINSULINISM AND GLYCOGEN DISEASE 1

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Abstract
2 adult cases of spontaneous hypoglycemia are briefly described, the one due to a carcinoma of the Langerhans islets with metastases to the liver and other organs (pancreatogenic hyperinsulinism), the other due to a massive fibroma on right top of the liver with possible blocking of the sympathetic pathways ("neurogenic" hyperinsulinism). In both cases glycogen detns. were made shortly after death in liver and muscle tissues, using the Good-Kramer-Somogyi method for glycogen precipitation and the Somogyi modification of the Shaffer-Hartmann method for glucose detn. Postmortem hepatic glycogenolysis was followed for 6 days in intact and sliced tissue, both at 37[degree] C and at ice box temp., in both cases as well as in normal control animals (rat, rabbit). A comparatively high liver and muscle glycogen and an approximately normal or slightly decreased postmortem hepatic glycogenolysis was demonstrated in the 2 cases. These findings were compared with those reported in von Gierke''s glycogen disease and the hyperinsulinism theory of the latter rejected.

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