Circulatory and Ventilatory Response to Exercise in Thyrotoxicosis

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Abstract
THYROTOXICOSIS is characterized by an increased basal metabolism. To provide the increased oxygen requirement, the respiratory and cardiovascular systems augment their minute output. However, at rest, both cardiac output1 , 2 and minute ventilation3 are increased disproportionately to the increase in oxygen consumption. In the case of minute ventilation, the rapid and shallow breathing pattern characteristic of thyrotoxicosis results in increased dead-space ventilation, the alveolar ventilation remaining normal.4 The elevation of cardiac output has been attributed to increased blood flow through the skin,1 , 2 , 5 and it has been suggested that both the increased respiratory and the circulatory responses serve a useful function by . . .

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