Utilization of Vitamin B12 by Rats With Pantothenic Acid Deficiency

Publisher Website
Google Scholar
Abstract
The metabolic pattern and the sparing effect of vitamin B12 were studied in pantothenic acid deficient rats with the following results: The liver of pantothenic acid deficient rats had higher vitamin B12 content than the control. The plasma vitamin B12 level, however, was not elevated in the deficient rats. Administration of a large dose of vitamin B12 to rats receiving a suboptimal dose of pantothenic acid had a sparing effect on survival rate. Absorption and excretion of radioactive vitamin B12 were not impaired in pantothenic acid deficiency. Radioactive vitamin B12 introduced either by intestinal absorption or by injection was retained more in the liver in pantothenic acid deficient rats than in the pantothenic acid supplemented control.

This publication has 2 references indexed in Scilit: