THE PRODUCTION OF EXPERIMENTAL POLYCYTHEMIA IN DOGS, RABBITS AND MAN BY THE DAILY ADMINISTRATION OF EPHEDRINE; AND BY AMPHETAMINE IN DOGS
- 31 August 1941
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 134 (2) , 219-224
- https://doi.org/10.1152/ajplegacy.1941.134.2.219
Abstract
The daily oral adm. of ephedrine sulfate to 4 normal dogs, in daily doses ranging from 2.5-5.0 mg. per kg., caused significant increases in the basal erythrocyte numbers of all of the animals within 10 to 15 days. Two normal and 2 splenectomized rabbits which received 45 mg. of ephedrine sulfate daily by subcut. inj. developed polycythemia with reticulocytosis within 2 wks. The daily inj. of ephedrine into 3 rabbits, which had a marked Co polycythemia, produced further appreciable increases in their erythrocyte numbers. A significant polycythemia was produced in 1 human subject in 2 wks. by the daily ingestion of 50 mg. of ephedrine sulfate. Total leukocyte counts did not increase. The oral adm. of 10 mg. of amphetamine sulfate daily to one splenectomized and 3 normal dogs caused significant increases in their basal erythrocyte counts and Hb % within 12 days.This publication has 1 reference indexed in Scilit:
- DEMONSTRATION THAT IN NORMAL MAN NO RESERVES OF BLOOD ARE MOBILIZED BY EXERCISE, EPINEPHRINE, AND HEMORRHAGEThe Lancet Healthy Longevity, 1941